COBRA PzF
NANOCOATED
STENT

Optimized Clinical Performance & Stent Deliverability

COBRA PzF Stent with Polyzene-F NanoCoating

The revolutionary COBRA PzF NanoCoated Coronary Stent (NCS) System is a new category of coronary stent that combines 1-month DAPT and the proprietary Polyzene-F nano-thin polymer for optimal treatment of high bleed risk patients who cannot tolerate long-term DAPT.

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Less Medication, More Independence

Requiring only 1-month DAPT regimen1, medical complications such as bleeding, and mortality associated with long-term DAPT may be reduced.2

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Innovation-Driven Outcomes

Polyzene-F nanocoating is a thrombo-resistant, nano-thin polymer that reduces inflammation by promoting rapid endothelialization. Learn more >

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Enhanced Deliverability

Thin strut, flexible cobalt chromium design with low crossing profile provides a smooth transition from tip to balloon, enabling enhanced deliverability through challenging anatomy.3

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More Efficient, Lower Cost of Care

Studying how to confidently treat high bleed risk patients to reduce the risk of bleeding, while lowering readmission rates. Learn more >

The COBRA PzF NanoCoated Stent aims to increase the safety and effectiveness of the intervention without having to rely on long-term medication compliance. Several studies have demonstrated low rates of stent thrombosis and zero late stent thrombosis.

COBRA Clinical Trials

1. Windecker et al. ESC/EACTS Guidelines. European Heart Journal. 2014; 35:2541-2690
2. Mauri et al. NEJM 2014; 371:2155-2166.anatomy.
3. Simulated use bench testing. Data on file.

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Product Ordering Information

The COBRA PzF NanoCoated Coronary Stent System is approved and commercially available for purchase throughout Europe and certain Middle Eastern countries. Contact a CeloNova sales representative today.

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Technology Redefined

Introducing the Revolutionary Polyzene-F NanoCoating

Polyzene-F (PzF) nanocoating is a cutting-edge, proprietary, nano-thin polymer with advanced properties designed to reduce complications and optimize outcomes.

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Thrombo-Resistant

PzF nanocoating resists thrombosis by selectively binding to the healthy protein, albumin, and repelling the harmful protein fibrinogen.4

Reduced Inflammation

150x thinner (0.05 µm) than a drug eluting stent coating, the PzF nano-thin protective layer works to reduce the inflammatory response.5

Rapid Endothelialization

PzF nanocoating may reduce the amount of dual anti-platelet therapy required by promoting rapid endothelialization.6

Clinically Tested, Revolutionary Polymer

The unique mechanism of action of Polyzene-F nanocoating has been shown to resist adhesion of platelets to the coated surface. With numerous peer-reviewed studies published to-date, Polyzene-F nanocoating’s properties allow for rapid healing.6

PzF Publications

Healing Response within Seconds

Polyzene-F nanocoating is a cutting-edge, proprietary, nano-thin polymer with advanced properties designed to reduce complications and optimize outcomes.

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Thrombo-Resistant Properties

The unique mechanism of action of Polyzene-F nanocoating has shown to resist adhesion of platelets to the coated surface in both bench and animal testing compared to DES and BMS.4

4. Mrowietz et al. Clinical Hemorheology and Microcirculation. 2005; 32:89-103.
5. Sakakura et al. EuroIntervention. May 22, 2013.
6. Tamburino et al. Interventional Cardiology. 2011; 3:451-460.

Resource Center

For peer-reviewed articles and other resources, please visit Clinical Resources.

Clinical Resources

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